• 介紹：

   Dioscin(CCRIS 4123; Collettiside III)是天然的植物來源的甾體皂苷，針對多種癌細胞有較好的抗癌活性。

• 熔點： 294-296 °C

• 比旋光度： D13 -115° (c = 0.373 in ethanol)

• 外觀： 白色或微黃的結晶性粉末

• 溶解性： DMSO  :  ≥  100  mg/mL  (115.07  mM)

• 敏感性： 易吸潮

• 儲存條件： 2-8℃

• 注意：部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

• 42. [3.8] Zhang Chenxu et al."Integrating network pharmacology and experimental validation to decipher the pharmacological mechanism of DXXK in treating diabetic kidney injury."Scientific Reports.2024 Sep;14(1):1-15

• 41. [IF=4.8] Chengfei Zhang et al."Dioscin Ameliorates Experimental Autoimmune Thyroiditis via the mTOR and TLR4/NF-κB Signaling."Drug Design Development and Therapy.

• 40. [IF=6.208] Weipeng Wang et al."The Functional Characterization of DzCYP72A12-4 Related to Diosgenin Biosynthesis and Drought Adaptability in Dioscorea zingiberensis."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2023 Jan;24(9):8430

• 39. [3.614] Gaodan Liu et al."Extraction and identification of steroidal saponins from Polygonatum cyrtonema Hua using natural deep eutectic solvent-synergistic quartz sand assisted extraction method."JOURNAL OF SEPARATION SCIENCE.2023 Feb;:2200823

• 38. [IF=5.168] Pan Wang et al."Discovery and characterization of novel ATP citrate lyase inhibitors from natural products by a luminescence-based assay."CHEMICO-BIOLOGICAL INTERACTIONS.2022 Nov;367:110199

• 37. [IF=4.412] Feng Su et al."Study of Chemical Compositions and Anticancer Effects of Paris polyphylla var. Chinensis Leaves."MOLECULES. 2022 Jan;27(9):2724

• 36. [IF=5.753] Jianghong Gao et al."Molecular Cloning and Functional Characterization of a Sterol 3-O-Glucosyltransferase Involved in Biosynthesis of Steroidal Saponins in Trigonella foenum-graecum.."Front Plant Sci. 2021 Dec;12:809579-809579

• 35. [IF=2.998] Wang Zhijuan et al.Preparation of dioscin from Trigonella foenum-graecum by foam separation–preparative high-performance liquid chromatography.European Food Research And Technology.2021 Nov 24

• 34. [IF=7.658] Yu-Xi Liu et al.Inhibition of Src/STAT3 signaling-mediated angiogenesis is involved in the anti-melanoma effects of dioscin.Pharmacol Res. 2022 Jan;175:105983

• 33. [IF=2.055] Jieru Han et al."Preventive effect of dioscin against monosodium urate-mediated gouty arthritis through inhibiting inflammasome NLRP3 and TLR4/NF-κB signaling pathway activation: an in vivo and in vitro study."J Nat Med-Tokyo. 2021 Jan;75(1):37-47

• 32. [IF=2.1] Yuyan Zhang et al."Tanshinone I and simvastatin inhibit melanoma tumour cell growth by regulating poly (ADP ribose) polymerase 1 expression."Mol Med Rep. 2021 Jan;23(1):1-1

• 31. [IF=2.289] Zhou Shun et al."Anthelmintic efficacy of natural saponins against Gyrodactylus kobayashii in goldfish (Carassius auratus) and their 3D-QSAR analysis."Parasitol Res. 2021 Mar;120(3):1143-1150

• 30. [IF=2.311] Yu?Xi Liu et al."Inhibiting the Src/STAT3 signaling pathway contributes to the anti?melanoma mechanisms of dioscin."Oncol Lett. 2020 Mar;19(3):2508-2514

• 29. [IF=3.412] Shun Zhou et al."Antiparasitic Efficacy of Herbal Extracts and Active Compound Against Gyrodactylus kobayashii in Carassius auratus."Front Vet Sci. 2021; 8: 665072

• 28. [IF=4.242] Shun Zhou et al."Anthelmintic efficacy of 35 herbal medicines against a monogenean parasite, Gyrodactylus kobayashii, infecting goldfish (Carassius auratus)."Aquaculture. 2020 May;521:734992

• 27. [IF=4.466] Yao Tan et al."Multiomics Integrative Analysis for Discovering the Potential Mechanism of Dioscin against Hyperuricemia Mice."J Proteome Res. 2021;20(1):645–660

• 26. [IF=4.952] Qun Yu et al."Enhancing the antityrosinase activity of saponins and polyphenols from Asparagus by hot air coupled with microwave treatments."Lwt Food Sci Technol. 2020 Apr;124:109174

• 25. [IF=5.645] Lixiu Hou et al."Geographical variations in fatty acid and steroid saponin biosynthesis in Dioscorea zingiberensis rhizomes."Ind Crop Prod. 2021 Oct;170:113779

• 24. [IF=5.923] Lixiu Hou et al."Genome-Wide Identification of CYP72A Gene Family and Expression Patterns Related to Jasmonic Acid Treatment and Steroidal Saponin Accumulation in Dioscorea zingiberensis."Int J Mol Sci. 2021 Jan;22(20):10953

• 23. [IF=2.998] Lei Lei et al."Preparation of diosgenin from Dioscorea zingiberensis C. H. Wright by stepwise biocatalysis-foam separation-preparative high-performance liquid chromatography (P-HPLC)."Eur Food Res Technol. 2018 Aug;244(8):1447-1452

• 22. [IF=3.998] Yang Rui et al."Dioscin relieves endotoxemia induced acute neuro-inflammation and protect neurogenesis via improving 5-HT metabolism."Sci Rep-Uk. 2017 Jan;7(1):1-13

• 21. [IF=4.759] Mengshun Liu et al."Folding fan mode counter-current chromatography offers fast blind screening for drug discovery. Case study: Finding anti-enterovirus 71 agents from Anemarrhena asphodeloides."J Chromatogr A. 2014 Nov;1368:116

• 20. Liu, Mengshun, et al. "Folding fan mode counter-current chromatography offers fast blind screening for drug discovery. Case study: Finding anti-enterovirus 71 agents from Anemarrhena asphodeloides." Journal of Chromatography A 1368 (2014): 116-124.https://

• 19. Wang, Peng, et al. "Ionic liquid-based ultrasonic/microwave-assisted extraction of steroidal saponins from Dioscorea zingiberensis CH Wright."?Tropical Journal of Pharmaceutical Research?13.8 (2014): 1339-1345.https://doi.org/10.4314/tjpr.v13i8.20

• 18. Tan, Yao, et al. "Multiomics integrative analysis for discovering the potential mechanism of dioscin against hyperuricemia mice." Journal of Proteome Research 20.1 (2020): 645-660.https://doi.org/10.1021/acs.jproteome.0c00584

• 17. 馬境謙,崔乃菠,余河水,李正,劉二偉,別松濤.基于4種皂苷的定量分析評價干燥方式對菊葉薯蕷有效成分的影響[J].中南藥學,2021,19(03):413-418.

• 16. 張劍,譚健聰,楊鈺蓉,張博,韓祿,劉春葉.響應曲面法優(yōu)化蒺藜中黃酮和皂苷的提取工藝[J].化工科技,2020,28(06):6-12.

• 15. 梁玉瓊,黃慶,梁天堅,汪磊,覃日宏,盤涌,滕麗娟,羅彩神.薯蕷皂苷對肝癌細胞Bel-7402和正常人肝細胞LO2增殖和凋亡的影響[J].中國比較醫(yī)學雜志,2021,31(03):30-35.

• 14. 賀子倩, 彭青, 蔡道琳,等. 狹葉蕁麻醇提物的體外抗氧化及抗炎活性[J]. 現代食品科技, 2018, v.34;No.228(08):42-49+135.

• 13. 朱昀, 王未, 李倩,等. 百合珠芽與鱗莖營養(yǎng)成分及活性成分研究[J]. 生物技術進展, 2016, 006(005):336-340.

• 12. 宋發(fā)軍 劉佳 張鵬 余曉東 吳瑞云. 重樓地上部分薯蕷皂苷含量的HPLC分析[J]. 中南民族大學學報:自然科學版, 2015(34):36-38.

• 11. 張亞欣, 王宇光, 馬增春,等. 薯蕷皂苷致肝毒性及其機制的初步研究[J]. 中國中藥雜志, 2015(14):2748-2752.

• 10. 李倩,巴寅穎,劉璐,申立峰,孫仁弟,張媛媛,孔靜,路東波,王夢林,石任兵.百合指標性成分含量測定及其特征圖譜質量表征關聯(lián)分析研究[J].環(huán)球中醫(yī)藥,2018,11(04):513-519.

• 9. 黃涵, 王宇卿. 瓜蔞薤白半夏膠囊提取工藝的優(yōu)化[J]. 中成藥, 2019, 41(02):182-185.

• 8. 孫鵬, 尹海波, 姚佳. 基于連作障礙條件下穿山龍皂苷類活性成分的含量變化[J]. 實用藥物與臨床, 2016(3):339-342,共4頁.

• 7. 姚佳, 尹海波, 趙容,等. 基于連作障礙條件下穿山龍無機元素吸收規(guī)律及總皂苷含量分析[J]. 中國實驗方劑學雜志, 2015, v.21(24):69-72.

• 6. 王仕寶 蘇瑩 李會寧 等. 響應面法優(yōu)化重樓藥材中甾體皂苷的回流提取工藝研究[J]. 陜西農業(yè)科學 2019 065(001):46-52.

• 5. 高行恩 賈永康 王洪新.不同烹飪工藝對淮山藥功能性成分的影響[J].食品研究與開發(fā) 2015 36(20):9-12.

• 4. 白橋 劉珍珍 徐皓.不同產地野生黃姜中薯蕷皂苷含量的比較[J].中國藥房 2019 30(05):681-684.

• 3. 賈曉晴 尹海波 陶玲 等. 不同產地穿山龍活性成分與環(huán)境因子相關性研究[J]. 遼寧中醫(yī)雜志 2017 04(v.44;No.479):154-158.

• 2. 王仕寶 蔡艷妮 賈慧梅 等. HPLC法測定不同來源重樓藥材中7種甾體皂苷的含量[J]. 西北藥學雜志 2017 32(002):133-138.

• 1. 楊亞利 劉佳 張鵬 等. 4種重樓不同部位薯蕷皂苷及皂苷元含量的分析[J]. 時珍國醫(yī)國藥 2016(5):1035-1038.

輸入產品批號：

本計算器可幫助您計算出特定溶液中溶質的質量、溶液濃度和體積之間的關系，公式為：

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *