• 介紹：

  Scutellarin 是從黃芩中分離到的黃酮類物質(zhì)，在 HCC 細(xì)胞中，能夠下調(diào) STAT3/Girdin/Akt 信號通路，在破骨細(xì)胞中，能夠抑制 RANKL 介導(dǎo)的 MAPK/NF-κB 信號通路。Scutellarin 具有抗 HIV-1IIIB，HIV-1(74V) 和 HIV-1KM018 的活性，EC₅₀ 分別為 26 μM，253 μM 和 136 μM。

• 熔點： 300-301°C

• 沸點： 891.6°C at 760 mmHg

• 比旋光度： -14°(水)，-139°(吡啶)

• 外觀： 黃色針狀結(jié)晶

• 溶解性： DMSO  :  100  mg/mL  (216.28  mM;  Need  ultrasonic)

• 儲存條件： 2-8℃

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

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• 41. [IF=4.6] Wei Yang et al."Synthesis and In Vivo Antiarrhythmic Activity Evaluation of Novel Scutellarein Analogues as Voltage-Gated Nav1.5 and Cav1.2 Channels Blockers."MOLECULES.2023 Jan;28(21):7417

• 40. [IF=3.4] Zhen Ma et al."Identification of chemical compounds of Schizonepeta tenuifolia Briq. and screening of neuraminidase inhibitors based on AUF-MS and SPR technology."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2024 Jan;237:115787

• 39. [IF=5.4] Yuming Yang et al."Taohong Siwu decoction reduces acute myocardial ischemia–reperfusion injury by promoting autophagy to inhibit pyroptosis."JOURNAL OF ETHNOPHARMACOLOGY.2024 Mar;321:117515

• 38. [IF=4.3] Bao-Fei Yan et al."Huangqin decoction alleviates lipid metabolism disorders and insulin resistance in nonalcoholic fatty liver disease by triggering Sirt1/NF-κB pathway."WORLD JOURNAL OF GASTROENTEROLOGY.2023 Aug 21; 29(31): 4744–4762

• 37. [5.195] Fuda Xie et al."Pathway network-based quantitative modeling of the time-dependent and dose-response anti-inflammatory effect of Reduning Injection."JOURNAL OF ETHNOPHARMACOLOGY.2023 May;307:116216

• 36. [IF=5.195] Weicong Chen et al."Biejiajian pill inhibits progression of hepatocellular carcinoma by downregulating PDGFRβ signaling in cancer-associated fibroblasts."JOURNAL OF ETHNOPHARMACOLOGY.2022 Oct;:115825

• 35. [IF=5.195] Xin Deng et al."A novel strategy for active compound efficacy status identification in multi-tropism Chinese herbal medicine (Scutellaria baicalensis Georgi) based on multi-indexes spectrum-effect gray correlation analysis."JOURNAL OF ETHNOPHARMACOLOGY.20

• 34. [IF=6.208] Pan Wang et al."Discovery of Flavonoids as Novel Inhibitors of ATP Citrate Lyase: Structure–Activity Relationship and Inhibition Profiles."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2022 Jan;23(18):10747

• 33. [IF=3.614] Huanyu Guan et al."Deciphering the chemical constituents of Shengjiang Xiexin decoction by ultra-high-performance liquid chromatography-quadrupole/orbitrap high-resolution mass spectrometry and the impact of 20 characteristic components on multidrug resis

• 32. [IF=5.195] Mengmeng Song et al."Homeostatic regulation of the aryl hydrocarbon receptor-cytochrome P450 1a axis by Scutellaria baicalensis-Coptis chinensis herb pair and its main constituents."JOURNAL OF ETHNOPHARMACOLOGY.2022 Jul;:115545

• 31. [IF=7.514] Jie Meng et al."Conduction of a chemical structure-guided metabolic phenotype analysis method targeting phenylpropane pathway via LC-MS: Ginkgo biloba and soybean as examples."FOOD CHEMISTRY. 2022 Oct;390:133155

• 30. [IF=3.935] Yizhu Wang et al."Effects of Scutellaria baicalensis Georgi. on Intestinal Flora in Rats with Spleen Deficiency and Damp-heat."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2022 May;:114831

• 29. [IF=1.448] Xiaoqin Zhong et al."Scutellarin?treated exosomes increase claudin 5, occludin and ZO1 expression in rat brain microvascular endothelial cells."Exp Ther Med. 2019 Jul;18(1):33-40

• 28. [IF=1.552] Fang Mingyue et al."Qualitative and Quantitative Analysis of 24 Components in Jinlianhua Decoction by UPLC–MS/MS."Chromatographia. 2019 Dec;82(12):1801-1825

• 27. [IF=2.952] Shao-Hua Ju et al."Scutellarin regulates osteoarthritis in vitro by inhibiting the PI3K/AKT/mTOR signaling pathway."Mol Med Rep. 2021 Jan;23(1):1-1

• 26. [IF=3.361] Fuen Liu et al."Scutellarin ameliorates cartilage degeneration in osteoarthritis by inhibiting the Wnt/β-catenin and MAPK signaling pathways."Int Immunopharmacol. 2020 Jan;78:105954

• 25. [IF=3.882] Kunpeng Yin et al."Lanthanide Metal–Organic Framework-Based Fluorescent Sensor Arrays to Discriminate and Quantify Ingredients of Natural Medicine."Langmuir. 2021;37(17):5321–5328

• 24. [IF=3.935] Meng Chen et al."Comprehensive analysis of Huanglian Jiedu decoction: Revealing the presence of a self-assembled phytochemical complex in its naturally-occurring precipitate."J Pharmaceut Biomed. 2021 Feb;195:113820

• 23. [IF=4.759] Yueping Jiang et al."Application of multifold characteristic ion filtering combined with statistical analysis for comprehensive profiling of chemical constituents in anti-renal interstitial fibrosis I decoction by ultra-high performance liquid chromatogra

• 22. [IF=5.11] Xiaonan Liu et al."De Novo Biosynthesis of Multiple Pinocembrin Derivatives in Saccharomyces cerevisiae."Acs Synth Biol. 2020;9(11):3042–3051

• 21. [IF=5.34] Shusheng Fan et al."Thymus quinquecostatus Celak. ameliorates cerebral ischemia-reperfusion injury via dual antioxidant actions: Activating Keap1/Nrf2/HO-1 signaling pathway and directly scavenging ROS."Phytomedicine. 2021 Oct;91:153673

• 20. [IF=6.023] Ying Liu et al."Mechanistic study of bergamottin-induced inactivation of CYP2C9."Food Chem Toxicol. 2021 Jul;153:112278

• 19. [IF=7.097] Jiezhou Ye et al."Scutellarin inhibits caspase-11 activation and pyroptosis in macrophages via regulating PKA signaling."Acta Pharm Sin B. 2021 Jan;11:112

• 18. [IF=1.851] Xinyu Hu et al."Pharmacological basis for application of scutellarin in Alzheimer's disease: Antioxidation and antiapoptosis."Mol Med Rep. 2018 Nov;18(5):4289-4296

• 17. [IF=1.902] Yining Zhao et al."Simultaneous quantitation of 23 bioactive compounds in Tanreqing capsule by high-performance liquid chromatography electrospray ionization tandem mass spectrometry."Biomed Chromatogr. 2019 Jul;33(7):e4531

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• 1. 田宇柔[1 3 4] 甄亞欽[1 3 4] 王鑫國[1 3 4] 李軍山[2 3 4] 牛麗穎[1 3 4]. 半枝蓮配方顆粒HPLC指紋圖譜及含量測定方法研究[J]. 中國藥學(xué)雜志 2016(51):1799.

輸入產(chǎn)品批號：

本計算器可幫助您計算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *