• 產(chǎn)品描述：

  MOMIPP，一種巨胞飲作用的誘導(dǎo)劑，是一種 PIKfyve 抑制劑。MOMIPP 可穿過(guò)血腦屏障 (BBB)。

• 靶點(diǎn)： PI3K

• 體外研究：
  MOMIPP can induce intense macropinocytosis, leading to methuosis in cultured glioblastoma cells at low micromolar concentrations[1].
  In U373 and Hs683 cell lines, 3 μM for MOMIPP induces cell vacuolization.
  MOMIPP (10?μM) causes early disruptions of glucose uptake and glycolytic metabolism. MOMIPP selectively activates the JNK1/2 stress kinase pathway, resulting in phosphorylation of c-Jun, Bcl-2 and Bcl-xL.

• 體內(nèi)研究：
  MOMIPP (80?mg/kg; i.p.; once daily; for 15 consecutive days) shows moderately effective in suppressing progression of intracerebral glioblastoma xenografts.

• 參考文獻(xiàn)：
  1.Margaux Colin, et al. Dysregulation of Macropinocytosis Processes in Glioblastomas May Be Exploited to Increase Intracellular Anti-Cancer Drug Levels: The Example of Temozolomide. Cancers (Basel). 2019 Mar 22;11(3):411.
  
  2.Zehui Li, et al. The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma. BMC Cancer. 2019 Jan 16;19(1):77.

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	3.421 ml	17.104 ml	34.208 ml
  5 mM	0.684 ml	3.421 ml	6.842 ml
  10 mM	0.342 ml	1.71 ml	3.421 ml
  50 mM	0.068 ml	0.342 ml	0.684 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號(hào)：

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *