• 產(chǎn)品描述： PS-48 是 phosphoinositide-dependent protein kinase-1 (PDK1) 的變構(gòu)激活劑

• 靶點： PDK1;PDK

• 體內(nèi)研究：
  In vivo, the PDK1 agonist PS48 can maintain the bone mass of mice treated with dexamethasone

• 細(xì)胞實驗： Cell lines: MC3T3-E1 cells Concentrations: 5 μM Incubation Time: -- Method: MC3T3-E1 cells are cultured in an osteogenic differentiation medium containing 4 mM glycerophosphate and 25 μg/mL ascorbic acid until 70% confluency. Dexamethasone (final concentration of ethanol, 0.01%, vol/vol) at different concentrations is then added to the osteogenic differentiation medium for 14 days. The culture medium is replaced every two days. MC3T3-E1 cells are cultured in a culture medium containing 10?7 M dexamethasone supplemented with or without PS48 (5 μM).

• 動物實驗： Animal Models: 8-week-old male C57BL/6J mice Dosages: -- Administration: --

• 參考文獻(xiàn)：
  1. Valerie Hindie, et al.Nat Chem Biol. 2009 Oct;5(10):758-64. 2. Wen-Ning Xu, et al. Front Endocrinol (Lausanne). 2020 Jan 28;10:922.

• 溶解性： Soluble  in  DMSO、Ethanol

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	3.487 ml	17.437 ml	34.873 ml
  5 mM	0.697 ml	3.487 ml	6.975 ml
  10 mM	0.349 ml	1.744 ml	3.487 ml
  50 mM	0.07 ml	0.349 ml	0.697 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號：

本計算器可幫助您計算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *