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• 產(chǎn)品描述： Sertindole (Lu 23-174) is an orally active?5-HT2A,?5-HT2C,?dopamine D2, and?αl-adrenergic?receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple?cancer?cells.

• 靶點： 5-HT2A Receptor;5-HT2C Receptor;DopamineReceptor;5-HTReceptor;AdrenergicReceptor;Autophagy

• 體內(nèi)研究：
  Sertindole (oral gavage; 10?mg/kg; once daily; 12 d) shows anti-tumor activity in vivo

• 參考文獻(xiàn)：
  1. David Murdoch, et al. Sertindole : a review of its use in schizophrenia. CNS Drugs. 2006;20(3):233-55. 2. Wei Zhang, et al. Antiproliferative activities of the second-generation antipsychotic drug sertindole against breast cancers with a potential application for treatment of breast-to-brain metastases. Sci Rep. 2018 Oct 25;8(1):15753. 3. Mario F Juruena, et al. Sertindole in the management of schizophrenia. J Cent Nerv Syst Dis. 2011 May 17;3:75-85.

• 溶解性： DMSO  :  25  mg/mL  (56.70  mM;  Need  ultrasonic)

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	2.268 ml	11.339 ml	22.679 ml
  5 mM	0.454 ml	2.268 ml	4.536 ml
  10 mM	0.227 ml	1.134 ml	2.268 ml
  50 mM	0.045 ml	0.227 ml	0.454 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號：

本計算器可幫助您計算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *