S80208 |
XMD8-87 |
| 源葉(MedMol) | 98% |
產品介紹
參考文獻
質檢證書(COA)
摩爾濃度計算器
相關產品
- 提示：詳情請下載說明書。
- 產品描述： XMD8-87 is a potent TNK2 inhibitor with IC50 values of 38 and 113 nM for the D163E and R806Q mutations, respectively
- 靶點： IC50: 38 nM (TNK2, D163E mutation), 113 nM (TNK2, R806Q mutation);Tyrosinase;PPAR
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體外研究：
XMD8-87 potently inhibits the growth of the TNK2 mutant expressing cell lines while having little or no effect on the control cells out to the highest tested concentrations (1,000 nM). XMD8-87 has IC50s of 38 nM and 113 nM for the D163E and R806Q mutations. The effects of XMD8-87 on TNK2 cell lines are largely due to on-target effects on TNK2. Auto-phosphorylation of overexpressed TNK2 mutants could be blocked with TNK2 inhibitor XMD8-87
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參考文獻：
1. Maxson JE, et al. Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis.
- 溶解性： soluble in DMSO
- 保存條件： -20℃
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配置溶液濃度參考：
1mg 5mg 10mg 1 mM 2.245 ml 11.223 ml 22.446 ml 5 mM 0.449 ml 2.245 ml 4.489 ml 10 mM 0.224 ml 1.122 ml 2.245 ml 50 mM 0.045 ml 0.224 ml 0.449 ml
- 注意：部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。
- 提示：詳情請下載說明書。
- 產品描述： XMD8-87 is a potent TNK2 inhibitor with IC50 values of 38 and 113 nM for the D163E and R806Q mutations, respectively
- 靶點： IC50: 38 nM (TNK2, D163E mutation), 113 nM (TNK2, R806Q mutation);Tyrosinase;PPAR
- 體外研究：
XMD8-87 potently inhibits the growth of the TNK2 mutant expressing cell lines while having little or no effect on the control cells out to the highest tested concentrations (1,000 nM). XMD8-87 has IC50s of 38 nM and 113 nM for the D163E and R806Q mutations. The effects of XMD8-87 on TNK2 cell lines are largely due to on-target effects on TNK2. Auto-phosphorylation of overexpressed TNK2 mutants could be blocked with TNK2 inhibitor XMD8-87
- 參考文獻：
1. Maxson JE, et al. Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis.
- 溶解性： soluble in DMSO
- 保存條件： -20℃
- 配置溶液濃度參考：
1mg 5mg 10mg 1 mM 2.245 ml 11.223 ml 22.446 ml 5 mM 0.449 ml 2.245 ml 4.489 ml 10 mM 0.224 ml 1.122 ml 2.245 ml 50 mM 0.045 ml 0.224 ml 0.449 ml
- 注意：部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。
輸入產品批號：
本計算器可幫助您計算出特定溶液中溶質的質量、溶液濃度和體積之間的關系，公式為：
質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)