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• 產(chǎn)品描述： ETP-46464 is an effective mTOR and ATR inhibitor with IC50s of 0.6 and 14 nM, respectively.

• 靶點(diǎn)： mTOR:0.6 nM (IC50);ATR:14 nM (IC50);ATM:545 nM (IC50);DNA-PK:36 nM (IC50);PI3Kα:170 nM (IC50);ATM/ATR;DNA-PK;PI3K;mTOR

• 參考文獻(xiàn)：
  1. Toledo LI, et al. A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations. Nat Struct Mol Biol. 2011 Jun;18(6):721-7. 2. Teng PN, et al. Pharmacologic inhibition of ATR and ATM offers clinically important distinctions to enhancing platinum or radiation response in ovarian, endometrial, and cervical cancer cells. Gynecol Oncol. 2015 Mar;136(3):554-61.

• 溶解性： DMSO  :  5  mg/mL  (10.63  mM;  Need  ultrasonic)

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	2.125 ml	10.627 ml	21.253 ml
  5 mM	0.425 ml	2.125 ml	4.251 ml
  10 mM	0.213 ml	1.063 ml	2.125 ml
  50 mM	0.043 ml	0.213 ml	0.425 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶(hù)參考交流研究之用。

輸入產(chǎn)品批號(hào)：

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *