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• 產(chǎn)品描述： Optovin is a reversible photoactivated TRPA1 ligand that enables light-mediated neuronal excitation. Optovin activates TRPA1 via structure-dependent photochemical reactions with redox-sensitive cysteine residues

• 靶點(diǎn)： TRP Channel;TRP/TRPVChannel

• 體外研究：
  Optovin (1-10 μM) increases Zebrafish embryos motor activity greater than 40 standard deviations above the control mean at the photic stimuli, with an EC50 of 2 μM. Optovin (100 μM; 120 s) strongly activates 33% (35/105) of dorsal root ganglia (DRG) neurons. Optovin (10 μM; 1 min) activates HEK293T cells transfected with hTrpA1

• 體內(nèi)研究：
  Optovin (1-10 μM) causes light-dependent motor excitation in vivo. Optovin (15 mM (20 μL); on the ear) elicits nociceptive behaviors in adult mice. Optovin (10 μM; 96 h) do not affect the appearance, touch response, heart rate, fin movements, morphology or percentage survival of larvae and adult zebrafish

• 參考文獻(xiàn)：
  1. Kokel D, et al. Photochemical activation of TRPA1 channels in neurons and animals. Nat Chem Biol. 2013 Apr;9(4):257-63.

• 溶解性： soluble  in  DMSO

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	3.17 ml	15.852 ml	31.704 ml
  5 mM	0.634 ml	3.17 ml	6.341 ml
  10 mM	0.317 ml	1.585 ml	3.17 ml
  50 mM	0.063 ml	0.317 ml	0.634 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號(hào)：

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *