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• 產(chǎn)品描述： PI4KIIIbeta-IN-9 is a potent PI4KIIIβ inhibitor with an IC50 of 7 nM. PI4KIIIbeta-IN-9 also inhibits PI3Kδ and PI3Kγ with IC50s of 152 nM and 1046 nM, respectively.

• 靶點(diǎn)： PI4KIIIβ:7 nM (IC50);PI4KIIIα:2.6 μM (IC50);PI3Kδ:152 nM (IC50);PI3Kγ:1046 nM (IC50);PI3Kα:2 μM (IC50);PI3KC2γ:1 μM (IC50);PI3K;?PI4K

• 體外研究：
  PI4KIIIbeta-IN-9 (Compound 9) shows weak inhibition of PI3KC2γ (IC50 ~1 μM), PI3Kα (~2 μM), and PI4KIIIα (~2.6 μM) and <50% inhibition at concentrations up to 20 μM for PI4K2α, PI4K2β, and PI3Kβ. PI4KIIIbeta-IN-9 (Compound 9) forms a crescent shape that conforms to the active site of PI4KIIIβ. This molecule makes extensive contacts with PI4KIIIβ

• 參考文獻(xiàn)：
  1. Rutaganira FU, et al. Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ. J Med Chem. 2016 Mar 10;59(5):1830-9.

• 溶解性： Soluble  in  DMSO

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	2.051 ml	10.254 ml	20.509 ml
  5 mM	0.41 ml	2.051 ml	4.102 ml
  10 mM	0.205 ml	1.025 ml	2.051 ml
  50 mM	0.041 ml	0.205 ml	0.41 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號(hào)：

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *