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• 產(chǎn)品描述： FICZ (6-Formylindolo[3,2-b]carbazole) 是一種 aryl hydrocarbon receptor (AhR) 的有效激動劑，可被AHR調(diào)節(jié)的細胞色素P4501酶有效地代謝

• 靶點： AhR;ArylHydrocarbonReceptor

• 體內(nèi)研究：
  FICZ improves the atopic dermatitis-like skin inflammation, clinical scores, and transepidermal water loss in NC/Nga mice compared with those of control mice. On histology, FICZ significantly reduces the epidermal and dermal thickness as well as the number of mast cells. Topical FICZ also significantly reduces the gene expression of Il22.

• 細胞實驗： Cell lines: Human immortalized HaCaT cells, normal human epidermal keratinocytes (NHEKs) Concentrations: 1 nM, 10 nM, 100 nM Incubation Time: 1 h, 3 h, 5 h Method: HaCaTcells or NHEKs (1×104 cells/well) are platedon an 8-well μ-slide for 48 h, and treated with or without FICZ for 3 or 1 h, respectively. Then, the cells are washed with phosphate-buffered saline (PBS), fixed with acetone for 10 min, and blocked with 5% (w/v) bovine serum albumin in PBS for 30 min. The cells are then incubated with primary rabbit anti-AHR antibody (1:100) overnight at 4 ℃. Specific binding is detected using a horseradish peroxidase-conjugated goat anti-rabbit anti-body followed by tyramide labeling with green-fluorescent Alexa Fluor 488 for 1 h at room temperature in accordance with the manufacturer's instructions.

• 動物實驗： Animal Models: 9–10 week-old female NC/Nga mice Dosages: 100 mg/affected area Administration: Topical

• 參考文獻：
  1. Emma Wincent, et al. Biochem Pharmacol. 2016 Jun 15;110-111:117-29. 2. Mari Kiyomatsu-Oda, et al. J Dermatol Sci. 2018 Jun;90(3):284-294.

• 溶解性： Soluble  in  DMSO

• 保存條件： 2-8℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	3.517 ml	17.586 ml	35.173 ml
  5 mM	0.703 ml	3.517 ml	7.035 ml
  10 mM	0.352 ml	1.759 ml	3.517 ml
  50 mM	0.07 ml	0.352 ml	0.703 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

• 1. [6.2] Meiqing Li et al."Epigallocatechin-3-gallate mitigates cadmium-induced intestinal damage through modulation of the microbiota-tryptophan-aryl hydrocarbon receptor pathway."ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY.2024 Jul;280:116520

輸入產(chǎn)品批號：

本計算器可幫助您計算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *