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S84286

BMT-145027

源葉(MedMol) 98%
  • 英文名:
  • BMT-145027
  • 別名:
  • CAS號:
  • 2018282-44-3
  • 分子式:
  • C23H14ClF3N4
  • 分子量:
  • 438.8322696
品牌貨號產(chǎn)品規(guī)格價格(RMB) 庫存(上海) 北京 武漢 南京 數(shù)量計量單位 加入購物車...
源葉(MedMol) S84286-1mg 98% ¥1100.00元 預計交期:2-3天 - - - EA 加入購物車
源葉(MedMol) S84286-5mg 98% ¥3300.00元 預計交期:2-3天 - - - EA 加入購物車
源葉(MedMol) S84286-10mg 98% ¥5000.00元 預計交期:2-3天 - - - EA 加入購物車
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參考文獻

質(zhì)檢證書(COA)

摩爾濃度計算器

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  • 提示:詳情請下載說明書。
  • 產(chǎn)品描述: BMT-145027 is an mGluR5 positive allosteric modulator without inherent agonist activity, exhibits an EC50 of 47 nM
  • 靶點: mGluR5:47 nM (EC50);GluR
  • 體外研究:
    BMT-145027 is a compound with high MsLM stability (85% remaining), acceptable potency (EC50=47 nM), and a modest decrease in planarity (Fsp3 = 0.17). Importantly, BMT-145027 lacks inherent mGluR5 agonist activity when tested at concentrations up to 16 μM
  • 體內(nèi)研究:
    Drug-treated and control mice are shown two identical objects. After a 24-h natural forgetting period, the mice are reintroduced to a familiar object while simultaneously presented with a novel object. Since mice spend more time exploring unfamiliar objects, improved memory is measured as time spent exploring the novel object. BMT-145027 leads to a significant increase in time spent with the novel object when dosed at 30 mg/kg, with an apparent trend in novel object preference at 10 mg/kg. Satellite animals indicates a total plasma concentration of 2800 nM at 30 mg/kg
  • 參考文獻:
    1. Hill MD, et al. Development of 1H-Pyrazolo[3,4-b]pyridines as Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators. ACS Med Chem Lett. 2016 Oct 3;7(12):1082-1086.
  • 溶解性: Soluble  in  DMSO
  • 保存條件: -20℃
  • 配置溶液濃度參考:
    1mg 5mg 10mg
    1 mM 2.279 ml 11.394 ml 22.788 ml
    5 mM 0.456 ml 2.279 ml 4.558 ml
    10 mM 0.228 ml 1.139 ml 2.279 ml
    50 mM 0.046 ml 0.228 ml 0.456 ml
  • 注意:部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權(quán)威性,僅供客戶參考交流研究之用。
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本計算器可幫助您計算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系,公式為:


質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)


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