• 產(chǎn)品描述： Imeglimin hydrochloride (EMD 387008) is an oral glucose-lowering agent. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function

• 靶點： ROS; mitochondrial function;ReactiveOxygenSpecies;MitochondrialMetabolism

• 體外研究：
  Preincubation with Imeglimin (10?mM for 4?h or 100?μM for 24?h) also fully prevented tert-butylhydroperoxide (tBH)-induced cell death. Cell Viability Assay Cell Line: Human endothelial cells (HMEC-1) Concentration: 100?μM and10?mM Incubation Time: 100?μM for 24?h, 10?mM for 4?h Result: Prevention of cell death.

• 體內(nèi)研究：
  Imeglimin (200 mg/kg b.i.d. by oral gavage during the last 6 weeks of HFHSD feeding) significantly decreases hyperglycemia, and restores normal glucose tolerance. Animal Model: Male C57BL/6JOlaHsd mice (4 weeks old) Dosage: 200 mg/kg Administration: Oral gavage; b.i.d.; 6 weeks Result: A slight decrease in body weight and food intake associated with some diarrhea was observed but only during the first few days of treatment.

• 參考文獻：
  1. Vial G, et al. Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrialfunction in liver of a high-fat, high-sucrose diet mice model. Diabetes. 2015 Jun;64(6):2254-64. 2. Detaille D, et al. Imeglimin prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration. Cell Death Discov. 2016 Jan 18;2:15072.

• 溶解性： Soluble  in  DMSO、H2O

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	5.218 ml	26.088 ml	52.175 ml
  5 mM	1.044 ml	5.218 ml	10.435 ml
  10 mM	0.522 ml	2.609 ml	5.218 ml
  50 mM	0.104 ml	0.522 ml	1.044 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號：

本計算器可幫助您計算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *